A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma

The aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.

Bibliographic Details
Published in:Pleura and Peritoneum
Main Authors: Krishnamurthy Kritika, Oh Kei Shing, Alghamdi Sarah, Sriganeshan Vathany, Poppiti Robert
Format: Article
Language:English
Published: De Gruyter 2023-03-01
Subjects:
Online Access:https://doi.org/10.1515/pp-2023-0003
_version_ 1848652315397980160
author Krishnamurthy Kritika
Oh Kei Shing
Alghamdi Sarah
Sriganeshan Vathany
Poppiti Robert
author_facet Krishnamurthy Kritika
Oh Kei Shing
Alghamdi Sarah
Sriganeshan Vathany
Poppiti Robert
author_sort Krishnamurthy Kritika
collection DOAJ
container_title Pleura and Peritoneum
description The aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.
format Article
id doaj-d591d62bea0c455c9fa2d791e6bf89bd
institution Directory of Open Access Journals
issn 2364-768X
language English
publishDate 2023-03-01
publisher De Gruyter
record_format Article
spelling doaj-d591d62bea0c455c9fa2d791e6bf89bd2025-11-02T22:57:10ZengDe GruyterPleura and Peritoneum2364-768X2023-03-0181192510.1515/pp-2023-0003A study of somatic BRCA variants and their putative effect on protein properties in malignant mesotheliomaKrishnamurthy Kritika0Oh Kei Shing1Alghamdi Sarah2Sriganeshan Vathany3Poppiti Robert4Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USAAM Rywlin Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, USAAM Rywlin Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, USAAM Rywlin Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, USAAM Rywlin Department of Pathology, Mount Sinai Medical Center, Miami Beach, FL, USAThe aim of this study is to analyze the prevalence of somatic mutations in BRCA1 and BRCA2 in malignant mesothelioma and their putative impact on protein properties.https://doi.org/10.1515/pp-2023-0003brcabrca1brca2disorder of proteinsmalignant mesotheliomasomatic variants
spellingShingle Krishnamurthy Kritika
Oh Kei Shing
Alghamdi Sarah
Sriganeshan Vathany
Poppiti Robert
A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
brca
brca1
brca2
disorder of proteins
malignant mesothelioma
somatic variants
title A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
title_full A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
title_fullStr A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
title_full_unstemmed A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
title_short A study of somatic BRCA variants and their putative effect on protein properties in malignant mesothelioma
title_sort study of somatic brca variants and their putative effect on protein properties in malignant mesothelioma
topic brca
brca1
brca2
disorder of proteins
malignant mesothelioma
somatic variants
url https://doi.org/10.1515/pp-2023-0003
work_keys_str_mv AT krishnamurthykritika astudyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT ohkeishing astudyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT alghamdisarah astudyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT sriganeshanvathany astudyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT poppitirobert astudyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT krishnamurthykritika studyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT ohkeishing studyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT alghamdisarah studyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT sriganeshanvathany studyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma
AT poppitirobert studyofsomaticbrcavariantsandtheirputativeeffectonproteinpropertiesinmalignantmesothelioma