| Summary: | ABSTRACT This case report highlights a temporal relationship between dexamethasone administration and the onset of Takotsubo cardiomyopathy, underscoring the importance of recognizing pharmacologic agents as potential non‐traditional triggers, particularly in patients with underlying cardiovascular disease and no identifiable emotional or physical stressors. Diagnosis favored a dexamethasone‐triggered Takotsubo phenotype based on non‐obstructive coronaries, regional wall‐motion abnormalities extending beyond a single arterial territory, absence of alternate stressors, and biologic plausibility of steroid‐mediated catecholaminergic upregulation.
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