Investigation of the in vitro performance difference of drug-Soluplus® and drug-PEG 6000 dispersions when prepared using spray drying or lyophilization

Purpose: To evaluate the physicochemical and in vitro characteristics of solid dispersions using BCS II model drugs with Soluplus® and one of its component homopolymers, PEG 6000. Methods: Nifedipine (NIF) and sulfamethoxazole (SMX) of 99.3% and 99.5% purity, respectively, were selected as BCS II mo...

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Bibliographic Details
Published in:	Saudi Pharmaceutical Journal
Main Authors:	Mohammad A. Altamimi, Steven H. Neau
Format:	Article
Language:	English
Published:	Springer 2017-03-01
Subjects:	Spray drying Lyophilization Dissolution Nifedipine Sulfamethoxazole Soluplus® PEG 6000 Solid dispersion
Online Access:	http://www.sciencedirect.com/science/article/pii/S1319016416301050

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