The Role of Add-On Lacosamide Therapy in the Treatment of Focal Onset Epilepsy

• Published in: Archives of Epilepsy
• Main Authors: Güray KOÇ, Semai BEK, Ömer KARADAŞ, Erdal EROĞLU, Zeki GÖKÇİL
• Format: Article
• Language: English
• Published: Turkish Epilepsy Society 2017-12-01
• Subjects: efficiency; focal epilepsy; lacosamide
• Online Access: http://archepilepsy.org/archives/archive-detail/article-preview/the-role-of-add-on-lacosamide-therapy-in-the-treat/54950

Objectives:The aim of this study was to retrospectively evaluate the efficacy and safety of lacosamide (200-300-400 mg/day) as adjunct treatment in patients with uncontrolled focal-onset seizures taking 2 or more antiepileptic drugs (AED).Methods:The medical records of patients with uncontrolled focal epilepsy who received lacosamide as add-on therapy for at least 6 months was reviewed retrospectively. The demographic data, the doses of lacosamide, concomitant AED therapy, and seizure activity in first and sixth months were analysed.Results:A total of 83 patients were evaluated. The mean percent reduction in seizure frequency per month was 38.98% in the first month and 33.22% in the sixth month. In all, 53% of the patients had a decrease in seizures of 50% or more in the first month, and 47% saw a similar decrease in the sixth month . The percentage of those taking a sodium channel blocking AED in addition to lacosamide was 97.6%. Dose-related adverse events reported included dizziness, nausea, diplopia, gastroenterological side effects, headache, itchy skin, and blurred vision. It was determined that all of the patients with drug-related side effects were taking a sodium channel blocking AED concomitantly with lacosamide.Conclusion:Adjuvant treatment with lacosamide reduced seizure frequency for patients with uncontrolled focal-onset seizures.