The Effect of Budesonide that is the Topical Corticosteroid on the Rat Nasal Mucosa (Experimental Study)

• Published in: Turkish Archives of Otorhinolaryngology
• Main Authors: Atila Güngör, Ethem Poyrazoğlu, Hasan Candan, Şükrü Yıldırım, Serhat Basutcu
• Format: Article
• Language: English
• Published: Turkish Otorhinolaryngology Head and Neck Surgery Society 2002-03-01
• Subjects: budesonide; corticosteroid; rat; topical.
• Online Access: http://turkarchotolaryngol.net/archives/archive-detail/article-preview/the-effect-of-budesonide-that-is-the-topical-corti/43811

In this study efficacy of frequently used topical corticosteroids in rhinitis of rat nose was investigated. Topical corticosteroid, budesonide was applied twice a day 10 μL into the noses of 10 rats in study group and serum physiologic was applied into noses of 6 rats in control group for 21 days. Histopathologic findings from three different sites, one from anterior site nearby incisor teeth, one from posterior site around hard palate and one from second tracheal ring were correlated. There were no significant differences regarding edema, ciliary loss and intraepithelial loss. Fibrosis, increase in epithelial thickness at anterior slides, infiltration of inflammatory cells at posterior slides and increase in goblet cells were found significant. Budesonide was found as a safe topical corticosteroid for nasal mucosa.