Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety
In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of 1H NMR and 13C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum o...
| 出版年: | Saudi Pharmaceutical Journal |
|---|---|
| 主要な著者: | , |
| フォーマット: | 論文 |
| 言語: | 英語 |
| 出版事項: |
Springer
2017-11-01
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| 主題: | |
| オンライン･アクセス: | http://www.sciencedirect.com/science/article/pii/S1319016417301214 |
| _version_ | 1848651131461304320 |
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| author | Łukasz Popiołek Anna Biernasiuk |
| author_facet | Łukasz Popiołek Anna Biernasiuk |
| author_sort | Łukasz Popiołek |
| collection | DOAJ |
| container_title | Saudi Pharmaceutical Journal |
| description | In this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of 1H NMR and 13C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28, 29, 32–43, and 45–48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002–7.81 µg/ml and MBC = 0.002–31.25 µg/ml). The levels of activity of several compounds were far better than those of nitrofurantoin, ciprofloxacin or cefuroxime. |
| format | Article |
| id | doaj-ec5cbeca258849efa0cdaa2540d6a1c2 |
| institution | Directory of Open Access Journals |
| issn | 1319-0164 |
| language | English |
| publishDate | 2017-11-01 |
| publisher | Springer |
| record_format | Article |
| spelling | doaj-ec5cbeca258849efa0cdaa2540d6a1c22025-11-03T01:24:54ZengSpringerSaudi Pharmaceutical Journal1319-01642017-11-012571097110210.1016/j.jsps.2017.05.006Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moietyŁukasz Popiołek0Anna Biernasiuk1Department of Organic Chemistry, Faculty of Pharmacy, Medical University of Lublin, 4A Chodźki Street, 20-093 Lublin, PolandDepartment of Pharmaceutical Microbiology, Faculty of Pharmacy, Medical University of Lublin, 1 Chodźki Street, 20-093 Lublin, PolandIn this research we synthesized and tested for in vitro antimicrobial activity 21 nitrofurazone analogues. The compounds we obtained were identified on the basis of 1H NMR and 13C NMR spectroscopy. The in vitro screening of antimicrobial properties of synthesized compounds revealed a wide spectrum of antimicrobial activity. Compounds 28, 29, 32–43, and 45–48 showed very high bactericidal effect towards Staphylococcus spp. ATTC and Bacillus spp. ATTC (MIC = 0.002–7.81 µg/ml and MBC = 0.002–31.25 µg/ml). The levels of activity of several compounds were far better than those of nitrofurantoin, ciprofloxacin or cefuroxime.http://www.sciencedirect.com/science/article/pii/S1319016417301214Nitrofurazone analoguesHydrazide-hydrazonesAntibacterial activityAntifungal activityMIC |
| spellingShingle | Łukasz Popiołek Anna Biernasiuk Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety Nitrofurazone analogues Hydrazide-hydrazones Antibacterial activity Antifungal activity MIC |
| title | Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety |
| title_full | Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety |
| title_fullStr | Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety |
| title_full_unstemmed | Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety |
| title_short | Synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide-hydrazone moiety |
| title_sort | synthesis and investigation of antimicrobial activities of nitrofurazone analogues containing hydrazide hydrazone moiety |
| topic | Nitrofurazone analogues Hydrazide-hydrazones Antibacterial activity Antifungal activity MIC |
| url | http://www.sciencedirect.com/science/article/pii/S1319016417301214 |
| work_keys_str_mv | AT łukaszpopiołek synthesisandinvestigationofantimicrobialactivitiesofnitrofurazoneanaloguescontaininghydrazidehydrazonemoiety AT annabiernasiuk synthesisandinvestigationofantimicrobialactivitiesofnitrofurazoneanaloguescontaininghydrazidehydrazonemoiety |