Search Results - CENTRAL NERVOUS SYSTEM AND PHARMACOTHERAPEUTICS

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    Pharmacotherapeutic profile, polypharmacy and its associated factors in a cohort of people living with HIV in Brazil by Robson Pierre Nascimento da Silva, Luana M. S. Marins, Lusiele Guaraldo, Paula Mendes Luz, Sandra W. Cardoso, Ronaldo I. Moreira, Vanessa da Gama Oliveira, Valdilea G. Veloso, Beatriz Grinsztejn, Rita Estrela, Thiago S. Torres

    Published in AIDS Research and Therapy (2023-08-01)
    “…Targeted interventions should be prioritized to prevent interactions and improve treatment, especially among individuals using central nervous system and cardiovascular medications, as well as certain groups such as cisgender women, older individuals and those with lower education. …”
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    Prevalence of polypharmacy and pharmacotherapy complexity in elderly people living with HIV in Spain. POINT study by Mercedes Gimeno-Gracia, Javier Sánchez-Rubio-Ferrández, María de las Aguas Robustillo-Cortés, Ramón Morillo-Verdugo

    Published in Farmacia Hospitalaria (2020-07-01)
    “…The median number of comorbidities was 3.5 (2.0-5.0), 52.7% of them being cardiovascular; 50.0% related to the central nervous system; 17.6% hepatic; and 8.1% consisting in chronic pulmonary disease. …”
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    Review of Intranasal Active Pharmaceutical Ingredient Delivery Systems by Ruslan Safarov, Olga Fedotova, Anastasia Uvarova, Mariia Gordienko, Natalia Menshutina

    Published in Pharmaceuticals (2024-09-01)
    “…In recent decades, there has been an increased interest in the development of intranasal delivery systems for active pharmaceutical ingredients (APIs) not only for treating local nasal diseases but also for treating systemic diseases, central nervous system (CNS) disorders, and vaccine delivery. …”
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    Effects of Intranasal Orexin-A (Hypocretin-1) Administration on Neuronal Activation, Neurochemistry, and Attention in Aged Rats by Coleman B. Calva, Habiba Fayyaz, Jim R. Fadel

    Published in Frontiers in Aging Neuroscience (2020-01-01)
    “…Fortunately, intranasal administration of native orexin peptides circumvents this issue and others concerning peptide transport into the central nervous system (CNS). To investigate the ability of intranasal orexin-A (OxA) administration to improve the anatomical, neurochemical, and behavioral substrates of age-related cognitive dysfunction, these studies utilized a rodent model of aging combined with acute intranasal administration of saline or OxA. …”
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    Investigation of key interactions between the second extracellular loop of dopamine D2 receptor and several hydroxy-N-{[2-(4-phenyl-piperaziny-1-yl)ethyl]phenyl}-nicotinamides by Šukalović Vladimir, Šoškić Vukić, Ignjatović Đurđica, Andrić Deana, Penјišević Jelena, Kostić-Rajačić Slađana

    Published in Journal of the Serbian Chemical Society (2014-01-01)
    “…Dopaminergic receptor system has been in focus for the development of new pharmacotherapeutic agents, targeting number of central nervous system related disorders, like drug addiction, schizophrenia, depression, and Parkinson's disease, just to name a few. …”
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    The involvement of K+ channels in depression and pharmacological effects of antidepressants on these channels by Xian-Tao Li

    Published in Translational Psychiatry (2024-10-01)
    “…It is well documented that K+ channels serve crucial roles in modulating the neuronal excitability and neurotransmitter release in the brain, and abnormality of these channels participated in the pathogenic process of diverse central nervous system (CNS) pathologies, such as seizure and Alzheimer’s disease (AD). …”
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