Search Results - MEDICINAL CHEMISTRY OF DRUGS

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    Exploring Subtilisin Inhibition to Discover Antimalarial Drugs: Insights into Medicinal Chemistry and Drug Discovery by Margarida Cochicho Leonardo, Sonaly Lima Albino, Wallyson Junio Santos de Araújo, Maria Verônica de Barros Nascimento, Juan David Rodríguez-Macías, Edgar Alexander Marquez Brazon, Ricardo Olimpio de Moura, Fátima Nogueira, Igor José dos Santos Nascimento

    Published in Pharmaceuticals (2025-09-01)
    “…<b>Conclusions</b>: Considering the relevance of this target, this review provided insights into medicinal chemistry, the discovery of antimalarial drugs that act by inhibiting subtilisin, and promoted a promising initiative to combat malaria.…”
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    Applications of Cucurbiturils in Medicinal Chemistry and Chemical Biology by Debapratim Das, Khaleel I. Assaf, Khaleel I. Assaf, Werner M. Nau

    Published in Frontiers in Chemistry (2019-09-01)
    “…The supramolecular chemistry of cucurbit[n]urils (CBn) has been rapidly developing to encompass diverse medicinal applications, including drug formulation and delivery, controlled drug release, and sensing for bioanalytical purposes. …”
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    Molecules with alkyne fragment in medicinal chemistry: The path from neurotoxins to drugs by Nataliya Zelisko, Roman Lesyk

    “…In this comprehensive review, we explore a diverse array of highly promising compounds, categorized based on their pharmacological properties, origins, and synthetic methodologies, to highlight the critical role of alkyne functionalities in advancing medicinal chemistry. Our analysis underscores the unique contributions of acetylene-containing compounds, emphasizing their structural significance and therapeutic potential.The remarkable versatility of acetylene-bearing molecules is evident in their wide-ranging biological activities, which position them as exceptional candidates for drug development. …”
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    From Plant to Chemistry: Sources of Antinociceptive Non-Opioid Active Principles for Medicinal Chemistry and Drug Design by Rita Turnaturi, Silvia Piana, Salvatore Spoto, Giuliana Costanzo, Lorena Reina, Lorella Pasquinucci, Carmela Parenti

    Published in Molecules (2024-02-01)
    “…As the process of pain transmission and modulation is regulated by different peripheral and central mechanisms and neurotransmitters, medicinal chemistry continues to study novel ligands and innovative approaches. …”
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    Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2 by Diego Muñoz-Torrero, Arduino A. Mangoni, Hong Liu, Christopher Hulme, Jarkko Rautio, Rafik Karaman, Maria Emília de Sousa, Katalin Prokai-Tatrai, Jean-Marc Sabatier, Carlo Siciliano, F. Javier Luque, George Kokotos, Rino Ragno, Simona Collina, Catherine Guillou, Michael Gütschow, Luigi A. Agrofoglio

    Published in Molecules (2017-12-01)
    “…Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes is a series of Editorials, which are published on a biannual basis by the Editorial Board of the Medicinal Chemistry section of the journal Molecules [...]…”
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    Pyrazine and Phenazine Heterocycles: Platforms for Total Synthesis and Drug Discovery by Robert W. Huigens, Beau R. Brummel, Srinivasarao Tenneti, Aaron T. Garrison, Tao Xiao

    Published in Molecules (2022-02-01)
    “…In addition, we cover some basic science related to pyrazine and phenazine heterocycles, which possess interesting reactivity profiles that have been on display in numerous cases of innovative total synthesis approaches, synthetic methodologies, drug discovery efforts, and medicinal chemistry programs. …”
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