Search Results - PHARMACOKINETICS AND BIOPHARMACEUTICS

Pharmacokinetics of Biopharmaceuticals: Their Critical Role in Molecular Design by Takuo Ogihara, Kenta Mizoi, Akiko Ishii-Watabe

Subjects: “…biopharmaceuticals…”
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The emerging role of physiologically-based pharmacokinetic/biopharmaceutics modeling in formulation development by Cvijić Sandra, Ignjatović Jelisaveta, Parojčić Jelena, Ibrić Svetlana

Subjects: “…physiologically-based pharmacokinetic modeling (pbpk)…”
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Biopharmaceutical and pharmacokinetic attributes to drive nanoformulations of small molecule tyrosine kinase inhibitors by Soumyadip Mukherjee, Vedant Joshi, Kolimi Prashanth Reddy, Nidhi Singh, Priyanka Das, Pallab Datta

“…However, some of these agents still encounter off-target toxicities and suboptimal efficacies due to their inferior biopharmaceutical and/or pharmacokinetic properties. Almost all of these molecules exhibit significant inter- and intra-patient variations in plasma concentration-time profiles. …”
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The Role of pharmacokinetics and biopharmaceutical investigations in the creation of a new dipeptide drugs (experimental investigation) by V. P. Zherdev, S. S. Boyko, R. V. Shevchenko, T. A. Gudasheva

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Understanding the mechanisms of food effect on omaveloxolone pharmacokinetics through physiologically based biopharmaceutics modeling by Xavier J. H. Pepin, Scott M. Hynes, Hamim Zahir, Deborah Walker, Lois Q. Semmens, Sandra Suarez‐Sharp

“…Here, physiologically based biopharmaceutics modeling (PBBM) was implemented to predict and explain the effect of the FDA high‐fat breakfast on a 150‐mg dose of omaveloxolone. …”
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Three-dimensional Biopharmaceutics and Clinical Considerations of Drugs for Safety and Efficacy: A Review Study by Sunday O. Awofisayo, Akwaowoh E. Akpabio, Emmanuel O. Olorunsola, Matthew I. Arhewoh

Subjects: “…biopharmaceutics…”
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Biopharmaceutical properties of polyvalent bacteriophage capsules by A. M. Nikolaeva, N. A. Kovyazina, E. V. Funkner, A. N. Krasilnikova, K. A. Lysko

Subjects: “…biopharmaceutical properties…”
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In Silico Evaluation of the Biopharmaceutical and Pharmacokinetic Behavior of Metronidazole from Coated Colonic Release Matrix Tablets by Roberto Arévalo-Pérez, Cristina Maderuelo, José M. Lanao

Subjects: “…physiologically based pharmacokinetic modeling (PBPK)…”
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Integrative green synthesis and molecular simulation of ibrutinib cocrystals for enhanced biopharmaceutical performance and in vivo pharmacokinetics by Divya Dhatri Kara, Pragathi Devanand Bangera, Mahesha Keerikkadu, Mahalaxmi Rathnanand

“…Bruton's tyrosine kinase (BTK) inhibitor, Ibrutinib (IBR), belongs to class II of the Biopharmaceutics Classification System (BCS). CYP3A4 enzyme forces IBR to have a very limited oral bioavailability. …”
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The Complexity of Bariatric Patient’s Pharmacotherapy: Sildenafil Biopharmaceutics and Pharmacokinetics before vs. after Gastric Sleeve/Bypass by Daniel Porat, Oleg Dukhno, Sandra Cvijić, Arik Dahan

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GastroPlus® as simulating/ conducting software for modeling physiologically-based pharmacokinetics & physiologically based biopharmaceutics. by Yasir Qasim Almajidi, Rafif Raad Faisal, Ahmed Yaseen, Maher abdulrazzaq luqman al-hakeem

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Integrating In Vitro BE Checker with In Silico Physiologically Based Biopharmaceutics Modeling to Predict the Pharmacokinetic Profiles of Oral Drug Products by Takuto Niino, Takato Masada, Toshihide Takagi, Makoto Kataoka, Hiroyuki Yoshida, Shinji Yamashita, Atsushi Kambayashi

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Combination of a biopharmaceutic classification system and physiologically based pharmacokinetic models to predict absorption properties of baicalein in vitro and in vivo by Yang Liu, Jing Sun, Linying Zhong, Yu Li, A Na Er, Tong Li, Le Yang, Ling Dong

Subjects: “…Biopharmaceutical classification system…”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

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Physiologically Based Biopharmaceutics Model of Apixaban for Biopharmaceutics Risk Assessment by Paulo Paixão, Zvonimir Petric, José A. G. Morais

“…<b>Background/Objectives:</b> This study applies a Physiologically Based Biopharmaceutics Modeling (PBBM) framework to predict the bioavailability (BA) and bioequivalence (BE) of apixaban, a borderline BCS Class III/IV drug. …”
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Tipifarnib physiologically‐based pharmacokinetic modeling to assess drug–drug interaction, organ impairment, and biopharmaceutics in healthy subjects and cancer patients by Noriko Okudaira, Howard Burt, Amitava Mitra

“…Abstract A physiologically‐based pharmacokinetic (PBPK) model for tipifarnib, which included mechanistic absorption, was built and verified by integrating in vitro data and several clinical data in healthy subjects and cancer patients. …”
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Biological and Biosimilar Medicines in Contemporary Pharmacotherapy for Metabolic Syndrome by Wiktoria Górecka, Daria Berezovska, Monika Mrozińska, Grażyna Nowicka, Monika E. Czerwińska

Subjects: “…biopharmaceutics…”
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Enteric Coating Enhances the Biopharmaceutical Performance of a Silica–Lipid Formulation of Abiraterone Acetate by Ali Taheri, Ruba Almasri, Anthony Wignall, Felicia Feltrin, Kristen E. Bremmell, Paul Joyce, Clive A. Prestidge

“…To address this, we evaluated an enteric coating strategy to preserve the biopharmaceutical performance of a silica-solidified lipid-based formulation. …”
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Biopharmaceutical profiling of anti-infective sanggenons from Morus alba root bark for inhalation administration by Jacqueline Schwarzinger, Sigrid Adelsberger, Karin Ortmayr, Sarah Luise Stellnberger, Ammar Tahir, Gabriela Hädrich, Verena Pichler, Judith M. Rollinger, Ulrike Grienke, Lea Ann Dailey

Subjects: “…Biopharmaceutical profiling…”
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Integrating In Vitro Dissolution and Physiologically Based Pharmacokinetic Modeling for Generic Drug Development: Evaluation of Amorphous Solid Dispersion Formulations for Tacrolim... by Evangelos Karakitsios, Maria-Faidra-Galini Angelerou, Iasonas Kapralos, Georgia Tsakiridou, Lida Kalantzi, Aristides Dokoumetzidis

“…<b>Objectives</b>: Tacrolimus, a Biopharmaceutics Classification System (BCS) class II drug, is widely used for transplant patients to prevent graft rejection. …”
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