Search Results - BIOPROCESS CONTROL AND INSTRUMENTATION

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    Digitization in bioprocessing: The role of soft sensors in monitoring and control of downstream processing for production of biotherapeutic products by Anurag Singh Rathore, Saxena Nikita, Naveen G. Jesubalan

    Published in Biosensors and Bioelectronics: X (2022-12-01)
    “…The model input is primarily composed of hardware signals from inline process sensors, analytical devices, actuators, and the instruments. This article offers an overview of soft sensing techniques in downstream bioprocessing for production of biotherapeutic products. …”
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    Benchmarking and Trends Around In-situ and Ex-situ Sensors in Bioreactors by David A. Pineda Rincon, David Camilo Corrales, Fayza Daboussi, Julien Cescut, Luc Fillaudeau, Cesar A. Aceves-Lara

    Published in Chemical Engineering Transactions (2025-07-01)
    “…Six major trends were identified, including the adoption of Process Analytical Technology (PAT) nomenclature, the growing use of optical and integrative instruments for real-time data, the vital role of soft sensors that estimate unmeasured variables, and the integration of AI into bioprocess monitoring and control. …”
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    Transcriptional response of <it>P. pastoris </it>in fed-batch cultivations to <it>Rhizopus oryzae </it>lipase production reveals UPR induction by Valero Francisco, Khatri Narendar K, Bollók Mónika, Resina David, Neubauer Peter, Ferrer Pau

    Published in Microbial Cell Factories (2007-07-01)
    “…</p> <p>Conclusion</p> <p>The bead-based sandwich hybridization assay has shown its potential as a reliable instrument for quantification of specific mRNA species in <it>P. pastoris </it>cells grown in fed-batch cultures. …”
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    Capillary Electrophoresis as a Monitoring Tool for Flow Composition Determination by Mihkel Kaljurand, Piret Saar-Reismaa, Merike Vaher, Jelena Gorbatsova, Jekaterina Mazina-Šinkar

    Published in Molecules (2021-08-01)
    “…In this paper, several ingenious approaches on interfacing flow from various chemical or bioprocesses to a capillary electrophoresis instrument are reviewed. …”
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