Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

by Andronesi, Ovidiu C., Kim, Grace S., Gerstner, Elizabeth R., Batchelor, Tracy T., Tzika, Aria A., Fantin, Valeria R., Vander Heiden, Matthew G., Sorensen, A. Gregory
Published 2014

mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient

by Freinkman, Elizaveta, Wyant, Gregory Andrew, Abu-Remaileh, Monther, Wolfson, Rachel Laura, Chen, Walter W., Danai, Laura V, Vander Heiden, Matthew G., Sabatini, David
Published 2018

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

by Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Chan, Sze Ham, Freinkman, Elizaveta, Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

PKM2 is not required for colon cancer initiated by APC loss

by Sinnamon, Mark J, Georgeon, Larissa, Yilmaz, Omer H, Di Vizio, Dolores, Hung, Kenneth E, Vander Heiden, Matthew G, Lau, Allison N., Israelsen, William J., Sinnamon, Mark J., Dayton, Talya L., Hillis, Alissandra L., Hung, Kenneth E., Israelsen, William James, Roper, Jatin, Yilmaz, Omer, Vander Heiden, Matthew G., Dayton, Talya Lucia
Published 2018

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

by Alkan, H. Furkan, Vesely, Paul W, Hackl, Hubert, Foßelteder, Johannes, Schmidt, Daniel, Vander Heiden, Matthew G., Pichler, Martin, Hoefler, Gerald, Bogner-Strauss, Juliane G
Published 2022

Human Phosphoglycerate Dehydrogenase Produces the Oncometabolite d-2-Hydroxyglutarate

by Teng, Xin, Liu, Ling, Looper, Ryan E., Rabinowitz, Joshua D., Vander Heiden, Matthew G., Mattaini, Katherine Ruth, Fan, Jing,M. Eng.Massachusetts Institute of Technology
Published 2016

Altered exocrine function can drive adipose wasting in early pancreatic cancer

by Danai, Laura V., Dennstedt, Emily A., Muir, Alexander, Lien, Evan C., Mayers, Jared R., Lau, Allison N., Jones-Sali, Paul, Vander Heiden, Matthew G.
Published 2020

Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

by Johnson, Marc O, Rathmell, Jeffrey C, Steinhauser, Matthew L, Hosios, Aaron Marc, Hecht, Vivian Chaya, Danai, Laura V, Manalis, Scott R, Vander Heiden, Matthew G.
Published 2018

Deficiency of malate-aspartate shuttle component SLC25A12 induces pulmonary metastasis

by Alkan, H. F, Vesely, Paul W, Hackl, Hubert, Foßelteder, Johannes, Schmidt, Daniel R, Vander Heiden, Matthew G, Pichler, Martin, Hoefler, Gerald, Bogner-Strauss, Juliane G
Published 2021

Quantification of microenvironmental metabolites in murine cancers reveals determinants of tumor nutrient availability

by Sullivan, Mark Robert, Danai, Laura V, Lewis, Caroline A, Chan, Sze Ham, Gui, Dan Yi, Kunchok, Tenzin, Dennstedt, Emily A, Vander Heiden, Matthew G., Muir, Alexander
Published 2021

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

by Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan Kristianne, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan M. E., Vander Heiden, Matthew G., Jacks, Tyler E.
Published 2018

Isoform-specific deletion of PKM2 constrains tumor initiation in a mouse model of soft tissue sarcoma

by Dayton, Talya L., Miller, Kathryn M., Bronson, Roderick T., Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn, Bhutkar, Arjun, Chidley, Caroline, Vander Heiden, Matthew G., Jacks, Tyler E.
Published 2018

Cell-State-Specific Metabolic Dependency in Hematopoiesis and Leukemogenesis

by Wang, Ying-Hua, Lee, Dongjun, Yu, Vionnie W.C, Jeanson, Nathaniel T, Clish, Clary B, Cantley, Lewis C, Scadden, David T, Israelsen, William James, Vander Heiden, Matthew G.
Published 2016

Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin

by Freinkman, Elizaveta, Thomas, Craig J., Gui, Dan Yi, Sullivan, Lucas Bryan, Luengo, Alba, Hosios, Aaron Marc, Bush, Lauren N., Gitego, Nadege, Davidson, Shawn M, Vander Heiden, Matthew G.
Published 2018

Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells

by Fendt, Sarah-Maria, Bell, Eric L., Mayers, Jared R., Vokes, Natalie I., Stephanopoulos, Gregory, Keibler, Mark Andrew, Wasylenko, Thomas Michael, Guarente, Leonard Pershing, Vander Heiden, Matthew G., Olenchock, Benjamin
Published 2014

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma

by Clish, Clary B., Bronson, Roderick T., Dayton, Talya L., Gocheva, Vasilena, Miller, Kathryn, Israelsen, William James, Bhutkar, Arjun, Davidson, Shawn Michael, Luengo, Alba, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2017

Aspartate is an endogenous metabolic limitation for tumour growth

by Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

Human Pancreatic Cancer Tumors Are Nutrient Poor and Tumor Cells Actively Scavenge Extracellular Protein

by Kamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Miller, G., Drebin, J. A., Bar-Sagi, D., Thompson, C. B., Rabinowitz, J. D., Vander Heiden, Matthew G.
Published 2016