From bench to patient: model systems in drug discovery

by Matthew D. Breyer, A. Thomas Look, Alessandra Cifra
Published 2015-10-01

The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.

by Jinhua Quan, Guillaume Adelmant, Jarrod A Marto, A Thomas Look, Timur Yusufzai
Published 2014-01-01

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies.

by Felix Oppel, Ting Tao, Hui Shi, Kenneth N Ross, Mark W Zimmerman, Shuning He, Guangxiang Tong, Jon C Aster, A Thomas Look
Published 2019-04-01

suz12 inactivation in p53- and nf1-deficient zebrafish accelerates the onset of malignant peripheral nerve sheath tumors and expands the spectrum of tumor types

by Felix Oppel, Dong H. Ki, Mark W. Zimmerman, Kenneth N. Ross, Ting Tao, Hui Shi, Shuning He, Jon C. Aster, A. Thomas Look
Published 2020-08-01

p27KIP1 Deletions in Childhood Acute Lymphoblastic Leukemia

by Hiroaki Komuro, Marcus B. Valentine, Jeffrey E. Rubnitz, Midori Saito, Susana C. Raimondi, Andrew J. Carroll, Taolin Yi, Charles J. Sherr, A. Thomas Look
Published 1999-08-01

Detection of MYCN Gene Amplification in Neuroblastoma by Fluorescence In Situ Hybridization: A Pediatric Oncology Group Study

by Prasad Mathew, Marcus B. Valentine, Laura C. Bowman, Susan T. Rowe, Michael B. Nash, Virginia A. Valentine, Susan L. Cohn, Robert P. Castleberry, Garrett M. Brodeur, A. Thomas Look
Published 2001-01-01

Disruption of asxl1 results in myeloproliferative neoplasms in zebrafish

by Evisa Gjini, Chang-Bin Jing, Ashley T. Nguyen, Deepak Reyon, Emma Gans, Michiel Kesarsing, Joshua Peterson, Olga Pozdnyakova, Scott J. Rodig, Marc R. Mansour, Keith Joung, A. Thomas Look
Published 2019-05-01

Lack of Homozygously Inactivated p73 in Single-Copy MYCN Primary Neuroblastomas and Neuroblastoma Cell Lines

by Xiao-Tang Kong, Virginia A. Valentine, Susan T. Rowe, Marcus B. Valentine, Susan T. Ragsdale, Bart G. Jones, Deborah A. Wilkinson, Garrett M. Brodeur, Susan L. Cohn, A. Thomas Look
Published 1999-04-01

Genome-wide analysis of neuroblastomas using high-density single nucleotide polymorphism arrays.

by Rani E George, Edward F Attiyeh, Shuli Li, Lisa A Moreau, Donna Neuberg, Cheng Li, Edward A Fox, Matthew Meyerson, Lisa Diller, Paolo Fortina, A Thomas Look, John M Maris
Published 2007-02-01

Ccdc94 protects cells from ionizing radiation by inhibiting the expression of p53.

by Shelly Sorrells, Seth Carbonneau, Erik Harrington, Aye T Chen, Bridgid Hast, Brett Milash, Ujwal Pyati, Michael B Major, Yi Zhou, Leonard I Zon, Rodney A Stewart, A Thomas Look, Cicely Jette
Published 2012-01-01

Critical Role for GAB2 in Neuroblastoma Pathogenesis through the Promotion of SHP2/MYCN Cooperation

by Xiaoling Zhang, Zhiwei Dong, Cheng Zhang, Choong Yong Ung, Shuning He, Ting Tao, Andre M. Oliveira, Alexander Meves, Baoan Ji, A. Thomas Look, Hu Li, Benjamin G. Neel, Shizhen Zhu
Published 2017-03-01

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

by Qin Tang, John C. Moore, Myron S. Ignatius, Inês M. Tenente, Madeline N. Hayes, Elaine G. Garcia, Nora Torres Yordán, Caitlin Bourque, Shuning He, Jessica S. Blackburn, A. Thomas Look, Yariv Houvras, David M. Langenau
Published 2016-01-01

MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy

by Stefan Heinrichs, Lillian F Conover, Carlos E Bueso-Ramos, Outi Kilpivaara, Kristen Stevenson, Donna Neuberg, Mignon L Loh, Wen-Shu Wu, Scott J Rodig, Guillermo Garcia-Manero, Hagop M Kantarjian, A Thomas Look
Published 2013-07-01

Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain

by Shuning He, Marc R Mansour, Mark W Zimmerman, Dong Hyuk Ki, Hillary M Layden, Koshi Akahane, Evisa Gjini, Eric D de Groh, Antonio R Perez-Atayde, Shizhen Zhu, Jonathan A Epstein, A Thomas Look
Published 2016-04-01

Small genomic insertions form enhancers that misregulate oncogenes

by Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Published 2017-02-01

Correction: Corrigendum: Small genomic insertions form enhancers that misregulate oncogenes

by Brian J. Abraham, Denes Hnisz, Abraham S. Weintraub, Nicholas Kwiatkowski, Charles H. Li, Zhaodong Li, Nina Weichert-Leahey, Sunniyat Rahman, Yu Liu, Julia Etchin, Benshang Li, Shuhong Shen, Tong Ihn Lee, Jinghui Zhang, A. Thomas Look, Marc R. Mansour, Richard A. Young
Published 2017-06-01

ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

by Lu Wang, Tze King Tan, Adam D. Durbin, Mark W. Zimmerman, Brian J. Abraham, Shi Hao Tan, Phuong Cao Thi Ngoc, Nina Weichert-Leahey, Koshi Akahane, Lee N. Lawton, Jo Lynne Rokita, John M. Maris, Richard A. Young, A. Thomas Look, Takaomi Sanda
Published 2019-12-01

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

by Jimann Shin, Arun Padmanabhan, Eric D. de Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
Published 2012-11-01

NOTCH1 signaling promotes human T-cell acute lymphoblastic leukemia initiating cell regeneration in supportive niches.

by Wenxue Ma, Alejandro Gutierrez, Daniel J Goff, Ifat Geron, Anil Sadarangani, Christina A M Jamieson, Angela C Court, Alice Y Shih, Qingfei Jiang, Christina C Wu, Kang Li, Kristen M Smith, Leslie A Crews, Neil W Gibson, Ida Deichaite, Sheldon R Morris, Ping Wei, Dennis A Carson, A Thomas Look, Catriona H M Jamieson
Published 2012-01-01

Integrative network analysis reveals USP7 haploinsufficiency inhibits E-protein activity in pediatric T-lineage acute lymphoblastic leukemia (T-ALL)

by Timothy I. Shaw, Li Dong, Liqing Tian, Chenxi Qian, Yu Liu, Bensheng Ju, Anthony High, Kanisha Kavdia, Vishwajeeth R. Pagala, Bridget Shaner, Deqing Pei, John Easton, Laura J. Janke, Shaina N. Porter, Xiaotu Ma, Cheng Cheng, Shondra M. Pruett-Miller, John Choi, Jiyang Yu, Junmin Peng, Wei Gu, A. Thomas Look, James R. Downing, Jinghui Zhang
Published 2021-03-01