Mapping the structural and dynamical features of multiple p53 DNA binding domains: insights into loop 1 intrinsic dynamics.

by Suryani Lukman, David P Lane, Chandra S Verma
Published 2013-01-01

Can Glycosylation Mask the Detection of MHC Expressing p53 Peptides by T Cell Receptors?

by Thanh Binh Nguyen, David P. Lane, Chandra S. Verma
Published 2021-07-01

Stapled BH3 peptides against MCL-1: mechanism and design using atomistic simulations.

by Thomas L Joseph, David P Lane, Chandra S Verma
Published 2012-01-01

Targeting ATM pathway for therapeutic intervention in cancer

by Hilal S Khalil, Hemanth Tummala, Stoyan Chakarov, Nikolai Zhelev, David P. Lane
Published 2012-07-01

A comparison and optimization of methods and factors affecting the transformation of Escherichia coli

by Weng‑Tat Chan, Chandra S. Verma, David P. Lane, Samuel Ken‑En Gan
Published 2013-12-01

Improved eIF4E binding peptides by phage display guided design: plasticity of interacting surfaces yield collective effects.

by Weizhuang Zhou, Soo T Quah, Chandra S Verma, Yun Liu, David P Lane, Christopher J Brown
Published 2012-01-01

Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly

by Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown
Published 2019-05-01

Enhancing the therapeutic effects of in vitro targeted radionuclide therapy of 3D multicellular tumor spheroids using the novel stapled MDM2/X-p53 antagonist PM2

by Anja C. L. Mortensen, Eric Morin, Christopher J. Brown, David P. Lane, Marika Nestor
Published 2020-04-01

Cancer Cells Shuttle Extracellular Vesicles Containing Oncogenic Mutant p53 Proteins to the Tumor Microenvironment

by Bibek Bhatta, Ishai Luz, Christian Krueger, Fanny Xueting Teo, David P. Lane, Kanaga Sabapathy, Tomer Cooks
Published 2021-06-01

A yeast two-hybrid system for the screening and characterization of small-molecule inhibitors of protein–protein interactions identifies a novel putative Mdm2-binding site in p53

by Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S. Verma, David P. Lane, Prakash Arumugam
Published 2017-11-01

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

by Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor
Published 2020-04-01

A general approach to protein folding using thermostable exoshells

by Samira Sadeghi, Siddharth Deshpande, Girish Vallerinteavide Mavelli, Alphan Aksoyoglu, Jayesh Bafna, Mathias Winterhalter, R. Manjunatha Kini, David P. Lane, Chester L. Drum
Published 2021-09-01

Structure-activity studies of Mdm2/Mdm4-binding stapled peptides comprising non-natural amino acids.

by Sharon Min Qi Chee, Jantana Wongsantichon, Jiawei Siau, Dawn Thean, Fernando Ferrer, Robert C Robinson, David P Lane, Christopher J Brown, Farid J Ghadessy
Published 2017-01-01

Structure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.

by Sharon Min Qi Chee, Jantana Wongsantichon, Quah Soo Tng, Robert Robinson, Thomas L Joseph, Chandra Verma, David P Lane, Christopher J Brown, Farid J Ghadessy
Published 2014-01-01

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine

by Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
Published 2021-08-01

Monoclonal Antibodies against Specific p53 Hotspot Mutants as Potential Tools for Precision Medicine

by Le-Ann Hwang, Beng Hooi Phang, Oi Wah Liew, Jabed Iqbal, Xiao Hui Koh, Xin Yu Koh, Rashidah Othman, Yuezhen Xue, A. Mark Richards, David P. Lane, Kanaga Sabapathy
Published 2018-01-01

Constitutive activation of WASp leads to abnormal cytotoxic cells with increased granzyme B and degranulation response to target cells

by Joanna S. Kritikou, Mariana M.S. Oliveira, Julien Record, Mezida B. Saeed, Saket M. Nigam, Minghui He, Marton Keszei, Arnika K. Wagner, Hanna Brauner, Anton Sendel, Saikiran K. Sedimbi, Stamatina Rentouli, David P. Lane, Scott B. Snapper, Klas Kärre, Peter Vandenberghe, Jordan S. Orange, Lisa S. Westerberg
Published 2021-03-01

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib.

by Marcus J G W Ladds, Andrés Pastor-Fernández, Gergana Popova, Ingeborg M M van Leeuwen, Kai Er Eng, Catherine J Drummond, Lars Johansson, Richard Svensson, Nicholas J Westwood, Anna R McCarthy, Fredrik Tholander, Mihaela Popa, David P Lane, Emmet McCormack, Gerald M McInerney, Ravi Bhatia, Sonia Laín
Published 2018-01-01

A Patient-Derived Cell Atlas Informs Precision Targeting of Glioblastoma

by Patrik Johansson, Cecilia Krona, Soumi Kundu, Milena Doroszko, Sathishkumar Baskaran, Linnéa Schmidt, Claire Vinel, Elin Almstedt, Ramy Elgendy, Ludmila Elfineh, Caroline Gallant, Sara Lundsten, Fernando J. Ferrer Gago, Aleksi Hakkarainen, Petra Sipilä, Maria Häggblad, Ulf Martens, Bo Lundgren, Melanie M. Frigault, David P. Lane, Fredrik J. Swartling, Lene Uhrbom, Marika Nestor, Silvia Marino, Sven Nelander
Published 2020-07-01

Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

by Li Ren Kong, Richard Weijie Ong, Tuan Zea Tan, Nur Afiqah Binte Mohamed Salleh, Matan Thangavelu, Jane Vin Chan, Lie Yong Judice Koh, Giridharan Periyasamy, Jieying Amelia Lau, Thi Bich Uyen Le, Lingzhi Wang, Miyoung Lee, Srinivasaraghavan Kannan, Chandra S. Verma, Chwee Ming Lim, Wee Joo Chng, David P. Lane, Ashok Venkitaraman, Huynh The Hung, Chit Fang Cheok, Boon Cher Goh
Published 2020-04-01