Acute Disease Animals Article C57BL mouse Colitis Cytokines Dextran Sulfate Disease Models, Animal Male Mice Mice, Inbred C57BL acute disease animal animal experiment animal model animal tissue chemically induced colitis controlled study cytokine dextran sulfate diarrhea disease model drug effect drug effects edema granulocyte colony stimulating factor granulocyte macrophage colony stimulating factor histopathology immunology