Sugar-Recognizing Ubiquitin Ligases: Action Mechanisms and Physiology

by Yukiko Yoshida, Tsunehiro Mizushima, Keiji Tanaka
Published 2019-02-01

Pseudosparse neural coding in the visual system of primates

by Sidney R. Lehky, Keiji Tanaka, Anne B. Sereno
Published 2021-01-01

Molecular and Structural Basis of the Proteasome α Subunit Assembly Mechanism Mediated by the Proteasome-Assembling Chaperone PAC3-PAC4 Heterodimer

by Tadashi Satoh, Maho Yagi-Utsumi, Kenta Okamoto, Eiji Kurimoto, Keiji Tanaka, Koichi Kato
Published 2019-05-01

Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4

by Yusuke Sato, Hikaru Tsuchiya, Atsushi Yamagata, Kei Okatsu, Keiji Tanaka, Yasushi Saeki, Shuya Fukai
Published 2019-12-01

Loss of Parkin contributes to mitochondrial turnover and dopaminergic neuronal loss in aged mice

by Sachiko Noda, Shigeto Sato, Takahiro Fukuda, Norihiro Tada, Yasuo Uchiyama, Keiji Tanaka, Nobutaka Hattori
Published 2020-03-01

Ub-ProT reveals global length and composition of protein ubiquitylation in cells

by Hikaru Tsuchiya, Daocharad Burana, Fumiaki Ohtake, Naoko Arai, Ai Kaiho, Masayuki Komada, Keiji Tanaka, Yasushi Saeki
Published 2018-02-01

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

by Masashi Watanabe, Hidehisa Takahashi, Yasushi Saeki, Takashi Ozaki, Shihori Itoh, Masanobu Suzuki, Wataru Mizushima, Keiji Tanaka, Shigetsugu Hatakeyama
Published 2015-04-01

Parkin mediates apparent E2-independent monoubiquitination in vitro and contains an intrinsic activity that catalyzes polyubiquitination.

by Katherine C M Chew, Noriyuki Matsuda, Keiko Saisho, Grace G Y Lim, Chou Chai, Hui-Mei Tan, Keiji Tanaka, Kah-Leong Lim
Published 2011-01-01

The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3.

by Taichi Kumanomidou, Kazuya Nishio, Kenji Takagi, Tomomi Nakagawa, Atsuo Suzuki, Takashi Yamane, Fuminori Tokunaga, Kazuhiro Iwai, Arisa Murakami, Yukiko Yoshida, Keiji Tanaka, Tsunehiro Mizushima
Published 2015-01-01

Foxn1-β5t transcriptional axis controls CD8+ T-cell production in the thymus

by Muhammad Myn Uddin, Izumi Ohigashi, Ryo Motosugi, Tomomi Nakayama, Mie Sakata, Jun Hamazaki, Yasumasa Nishito, Immanuel Rode, Keiji Tanaka, Tatsuya Takemoto, Shigeo Murata, Yousuke Takahama
Published 2017-02-01

The CD40-autophagy pathway is needed for host protection despite IFN-Γ-dependent immunity and CD40 induces autophagy via control of P21 levels.

by Jose-Andres C Portillo, Genevieve Okenka, Erin Reed, Angela Subauste, Jennifer Van Grol, Katrin Gentil, Masaaki Komatsu, Keiji Tanaka, Gary Landreth, Beth Levine, Carlos S Subauste
Published 2010-12-01

Ubiquitination of stalled ribosome triggers ribosome-associated quality control

by Yoshitaka Matsuo, Ken Ikeuchi, Yasushi Saeki, Shintaro Iwasaki, Christian Schmidt, Tsuyoshi Udagawa, Fumiya Sato, Hikaru Tsuchiya, Thomas Becker, Keiji Tanaka, Nicholas T. Ingolia, Roland Beckmann, Toshifumi Inada
Published 2017-07-01

Endosomal Rab cycles regulate Parkin-mediated mitophagy

by Koji Yamano, Chunxin Wang, Shireen A Sarraf, Christian Münch, Reika Kikuchi, Nobuo N Noda, Yohei Hizukuri, Masato T Kanemaki, Wade Harper, Keiji Tanaka, Noriyuki Matsuda, Richard J Youle
Published 2018-01-01

The role of Purkinje fibers in the emergence of an incessant form of polymorphic ventricular tachycardia or ventricular fibrillation associated with ischemic heart disease

by Yoshinori Kobayashi, MD, Yu-ki Iwasaki, MD, Yasushi Miyauchi, MD, Meiso Hayashi, MD, Norihiko Ohno, MD, Kenji Yodogawa, MD, Norishige Morita, MD, Keiji Tanaka, MD, Kyouichi Mizuno, MD
Published 2008-01-01

HTLV-1 Tax Induces Formation of the Active Macromolecular IKK Complex by Generating Lys63- and Met1-Linked Hybrid Polyubiquitin Chains.

by Yuri Shibata, Fuminori Tokunaga, Eiji Goto, Ginga Komatsu, Jin Gohda, Yasushi Saeki, Keiji Tanaka, Hirotaka Takahashi, Tatsuya Sawasaki, Satoshi Inoue, Hiroyuki Oshiumi, Tsukasa Seya, Hiroyasu Nakano, Yuetsu Tanaka, Kazuhiro Iwai, Jun-Ichiro Inoue
Published 2017-01-01

Mitochondrial Complexes I and II Are More Susceptible to Autophagy Deficiency in Mouse β-Cells

by Min Joo Kim, Ok Kyong Choi, Kyung Sil Chae, Min Kyeong Kim, Jung Hee Kim, Masaaki Komatsu, Keiji Tanaka, Hakmo Lee, Sung Soo Chung, Soo Heon Kwak, Young Min Cho, Kyong Soo Park, Hye Seung Jung
Published 2015-03-01

Trans-omics Impact of Thymoproteasome in Cortical Thymic Epithelial Cells

by Izumi Ohigashi, Yu Tanaka, Kenta Kondo, Sayumi Fujimori, Hiroyuki Kondo, Amy C. Palin, Victoria Hoffmann, Mina Kozai, Yosuke Matsushita, Shinsuke Uda, Ryo Motosugi, Jun Hamazaki, Hiroyuki Kubota, Shigeo Murata, Keiji Tanaka, Toyomasa Katagiri, Hidetaka Kosako, Yousuke Takahama
Published 2019-11-01

Fluctuations of Spleen Cytokine and Blood Lactate, Importance of Cellular Immunity in Host Defense Against Blood Stage Malaria Plasmodium yoelii

by Takashi Imai, Takashi Imai, Kazutomo Suzue, Ha Ngo-Thanh, Suguri Ono, Wakako Orita, Haruka Suzuki, Chikako Shimokawa, Chikako Shimokawa, Alex Olia, Alex Olia, Seiji Obi, Tomoyo Taniguchi, Hidekazu Ishida, Luc Van Kaer, Shigeo Murata, Keiji Tanaka, Hajime Hisaeda
Published 2019-09-01

Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation

by Atsuya Nishiyama, Christopher B. Mulholland, Sebastian Bultmann, Satomi Kori, Akinori Endo, Yasushi Saeki, Weihua Qin, Carina Trummer, Yoshie Chiba, Haruka Yokoyama, Soichiro Kumamoto, Toru Kawakami, Hironobu Hojo, Genta Nagae, Hiroyuki Aburatani, Keiji Tanaka, Kyohei Arita, Heinrich Leonhardt, Makoto Nakanishi
Published 2020-03-01

Inhibitory effects of local anesthetics on the proteasome and their biological actions

by Udin Bahrudin, Masaki Unno, Kazuya Nishio, Akiko Kita, Peili Li, Masaru Kato, Masashi Inoue, Shunichi Tsujitani, Takuto Murakami, Rina Sugiyama, Yasushi Saeki, Yuji Obara, Keiji Tanaka, Hiroshi Yamaguchi, Isao Sakane, Yasushi Kawata, Toshiyuki Itoh, Haruaki Ninomiya, Ichiro Hisatome, Yukio Morimoto
Published 2017-07-01