A novel GIT2-BRAF fusion in pilocytic astrocytoma

by Jeffrey Helgager, Hart G. Lidov, Navin R. Mahadevan, Mark W. Kieran, Keith L. Ligon, Sanda Alexandrescu
Published 2017-11-01

Prominin-1 (CD133) defines both stem and non-stem cell populations in CNS development and gliomas.

by Karl Holmberg Olausson, Cecile L Maire, Sam Haidar, Jason Ling, Emily Learner, Monica Nistér, Keith L Ligon
Published 2014-01-01

Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell–derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity

by Jessian L Munoz, Sarah A Bliss, Steven J Greco, Shakti H Ramkissoon, Keith L Ligon, Pranela Rameshwar
Published 2013-01-01

CRX is a diagnostic marker of retinal and pineal lineage tumors.

by Sandro Santagata, Cecile L Maire, Ahmed Idbaih, Lars Geffers, Mick Correll, Kristina Holton, John Quackenbush, Keith L Ligon
Published 2009-11-01

Microfluidic active loading of single cells enables analysis of complex clinical specimens

by Nicholas L. Calistri, Robert J. Kimmerling, Seth W. Malinowski, Mehdi Touat, Mark M. Stevens, Selim Olcum, Keith L. Ligon, Scott R. Manalis
Published 2018-11-01

Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models

by Max A. Stockslager, Seth Malinowski, Mehdi Touat, Jennifer C. Yoon, Jack Geduldig, Mahnoor Mirza, Annette S. Kim, Patrick Y. Wen, Kin-Hoe Chow, Keith L. Ligon, Scott R. Manalis
Published 2021-10-01

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.

by Dora Dias-Santagata, Quynh Lam, Kathy Vernovsky, Natalie Vena, Jochen K Lennerz, Darrell R Borger, Tracy T Batchelor, Keith L Ligon, A John Iafrate, Azra H Ligon, David N Louis, Sandro Santagata
Published 2011-03-01

Linking single-cell measurements of mass, growth rate, and gene expression

by Robert J. Kimmerling, Sanjay M. Prakadan, Alejandro J. Gupta, Nicholas L. Calistri, Mark M. Stevens, Selim Olcum, Nathan Cermak, Riley S. Drake, Kristine Pelton, Frederik De Smet, Keith L. Ligon, Alex K. Shalek, Scott R. Manalis
Published 2018-11-01

Somatic mutations of PIK3R1 promote gliomagenesis.

by Steven N Quayle, Jennifer Y Lee, Lydia W T Cheung, Li Ding, Ruprecht Wiedemeyer, Robert W Dewan, Emmet Huang-Hobbs, Li Zhuang, Richard K Wilson, Keith L Ligon, Gordon B Mills, Lewis C Cantley, Lynda Chin
Published 2012-01-01

Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway

by Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Published 2017-06-01

Post-translational Modifications of OLIG2 Regulate Glioma Invasion through the TGF-β Pathway

by Shiv K. Singh, Roberto Fiorelli, Robert Kupp, Sindhu Rajan, Emily Szeto, Costanza Lo Cascio, Cecile L. Maire, Yu Sun, John A. Alberta, Jennifer M. Eschbacher, Keith L. Ligon, Michael E. Berens, Nader Sanai, Shwetal Mehta
Published 2016-07-01

The functional synergism of microRNA clustering provides therapeutically relevant epigenetic interference in glioblastoma

by Vivek Bhaskaran, Michal O. Nowicki, Mahmoud Idriss, Miguel A. Jimenez, Gianmarco Lugli, Josie L. Hayes, Ahmad Bakur Mahmoud, Rachel E. Zane, Carmela Passaro, Keith L. Ligon, Daphne Haas-Kogan, Agnieszka Bronisz, Jakub Godlewski, Sean E. Lawler, E. Antonio Chiocca, Pierpaolo Peruzzi
Published 2019-01-01

DNA fragmentation simulation method (FSM) and fragment size matching improve aCGH performance of FFPE tissues.

by Justin M Craig, Natalie Vena, Shakti Ramkissoon, Ahmed Idbaih, Shaun D Fouse, Memet Ozek, Aydin Sav, D Ashley Hill, Linda R Margraf, Charles G Eberhart, Mark W Kieran, Andrew D Norden, Patrick Y Wen, Massimo Loda, Sandro Santagata, Keith L Ligon, Azra H Ligon
Published 2012-01-01

Molecular and clinicopathologic features of gliomas harboring NTRK fusions

by Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H. Ligon, Fei Dong, David M. Meredith, MacLean P. Nasrallah, Craig Horbinski, Sonika Dahiya, Keith L. Ligon, Mariarita Santi, Shakti H. Ramkissoon, Mariella G. Filbin, Matija Snuderl, Sanda Alexandrescu
Published 2020-07-01

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2

by Jing Zhou, An-Chi Tien, John A. Alberta, Scott B. Ficarro, Amelie Griveau, Yu Sun, Janhavee S. Deshpande, Joseph D. Card, Meghan Morgan-Smith, Wojciech Michowski, Rintaro Hashizume, C. David James, Keith L. Ligon, William D. Snider, Peter Sicinski, Jarrod A. Marto, David H. Rowitch, Charles D. Stiles
Published 2017-03-01

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

by Jimann Shin, Arun Padmanabhan, Eric D. de Groh, Jeong-Soo Lee, Sam Haidar, Suzanne Dahlberg, Feng Guo, Shuning He, Marc A. Wolman, Michael Granato, Nathan D. Lawson, Scot A. Wolfe, Seok-Hyung Kim, Lilianna Solnica-Krezel, John P. Kanki, Keith L. Ligon, Jonathan A. Epstein, A. Thomas Look
Published 2012-11-01

A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine

by Hyun Jung Jun, Vicky A. Appleman, Hua-Jun Wu, Christopher M. Rose, Javier J. Pineda, Alan T. Yeo, Bethany Delcuze, Charlotte Lee, Aron Gyuris, Haihao Zhu, Steve Woolfenden, Agnieszka Bronisz, Ichiro Nakano, Ennio A. Chiocca, Roderick T. Bronson, Keith L. Ligon, Jann N. Sarkaria, Steve P. Gygi, Franziska Michor, Timothy J. Mitchison, Al Charest
Published 2018-08-01

Spatial and temporal homogeneity of driver mutations in diffuse intrinsic pontine glioma

by Hamid Nikbakht, Eshini Panditharatna, Leonie G. Mikael, Rui Li, Tenzin Gayden, Matthew Osmond, Cheng-Ying Ho, Madhuri Kambhampati, Eugene I. Hwang, Damien Faury, Alan Siu, Simon Papillon-Cavanagh, Denise Bechet, Keith L. Ligon, Benjamin Ellezam, Wendy J. Ingram, Caedyn Stinson, Andrew S. Moore, Katherine E. Warren, Jason Karamchandani, Roger J. Packer, Nada Jabado, Jacek Majewski, Javad Nazarian
Published 2016-04-01

ZFHX4 Interacts with the NuRD Core Member CHD4 and Regulates the Glioblastoma Tumor-Initiating Cell State

by Yakov Chudnovsky, Dohoon Kim, Siyuan Zheng, Warren A. Whyte, Mukesh Bansal, Mark-Anthony Bray, Shuba Gopal, Matthew A. Theisen, Steve Bilodeau, Prathapan Thiru, Julien Muffat, Omer H. Yilmaz, Maya Mitalipova, Kevin Woolard, Jeongwu Lee, Riko Nishimura, Nobuo Sakata, Howard A. Fine, Anne E. Carpenter, Serena J. Silver, Roel G.W. Verhaak, Andrea Califano, Richard A. Young, Keith L. Ligon, Ingo K. Mellinghoff, David E. Root, David M. Sabatini, William C. Hahn, Milan G. Chheda
Published 2014-01-01

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

by Zachary J. Reitman, Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, Hayley Malkin, Ying Huang, Leslie Grimmet, Zachary T. Herbert, Yu Sun, Jessica L. Weatherbee, John A. Alberta, John F. Daley, Orit Rozenblatt-Rosen, Alexandra L. Condurat, Kenin Qian, Prasidda Khadka, Rosalind A. Segal, Daphne Haas-Kogan, Mariella G. Filbin, Mario L. Suva, Aviv Regev, Charles D. Stiles, Mark W. Kieran, Liliana Goumnerova, Keith L. Ligon, Alex K. Shalek, Pratiti Bandopadhayay, Rameen Beroukhim
Published 2019-08-01