The role of ER stress in lipid metabolism and lipotoxicity

by Jaeseok Han, Randal J. Kaufman
Published 2016-08-01

Glycoprotein folding and quality-control mechanisms in protein-folding diseases

by Sean P. Ferris, Vamsi K. Kodali, Randal J. Kaufman
Published 2014-03-01

Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans.

by Xiaohua Shen, Ronald E Ellis, Kenjiro Sakaki, Randal J Kaufman
Published 2005-09-01

The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts

by Winston T. Stauffer, Erik A. Blackwood, Khalid Azizi, Randal J. Kaufman, Christopher C. Glembotski
Published 2020-02-01

Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mous...

by Katherine R Sadleir, William A Eimer, Randal J Kaufman, Pavel Osten, Robert Vassar
Published 2014-01-01

ATF6 is required for efficient rhodopsin clearance and retinal homeostasis in the P23H rho retinitis pigmentosa mouse model

by Eun-Jin Lee, Priscilla Chan, Leon Chea, Kyle Kim, Randal J. Kaufman, Jonathan H. Lin
Published 2021-08-01

Mitochondria supply ATP to the ER through a mechanism antagonized by cytosolic Ca2+

by Jing Yong, Helmut Bischof, Sandra Burgstaller, Marina Siirin, Anne Murphy, Roland Malli, Randal J Kaufman
Published 2019-09-01

Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network

by Angela M Arensdorf, Diane eDeZwaan McCabe, Randal J Kaufman, D Thomas Rutkowski
Published 2013-09-01

Transcription Factor ATF4 Induces NLRP1 Inflammasome Expression during Endoplasmic Reticulum Stress.

by Andrea D'Osualdo, Veronica G Anania, Kebing Yu, Jennie R Lill, Randal J Kaufman, Shu-ichi Matsuzawa, John C Reed
Published 2015-01-01

Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data.

by Yongsheng Bai, Justin Hassler, Ahdad Ziyar, Philip Li, Zachary Wright, Rajasree Menon, Gilbert S Omenn, James D Cavalcoli, Randal J Kaufman, Maureen A Sartor
Published 2014-01-01

Concomitant Nrf2- and ATF4-Activation by Carnosic Acid Cooperatively Induces Expression of Cytoprotective Genes

by Junsei Mimura, Atsushi Inose-Maruyama, Shusuke Taniuchi, Kunio Kosaka, Hidemi Yoshida, Hiromi Yamazaki, Shuya Kasai, Nobuhiko Harada, Randal J. Kaufman, Seiichi Oyadomari, Ken Itoh
Published 2019-04-01

eIF2α-mediated translational control regulates the persistence of cocaine-induced LTP in midbrain dopamine neurons

by Andon N Placzek, Gonzalo Viana Di Prisco, Sanjeev Khatiwada, Martina Sgritta, Wei Huang, Krešimir Krnjević, Randal J Kaufman, John A Dani, Peter Walter, Mauro Costa-Mattioli
Published 2016-12-01

Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins.

by D Thomas Rutkowski, Stacey M Arnold, Corey N Miller, Jun Wu, Jack Li, Kathryn M Gunnison, Kazutoshi Mori, Amir A Sadighi Akha, David Raden, Randal J Kaufman
Published 2006-11-01

Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

by Huabin Zhu, Brinda Bhatt, Sathish Sivaprakasam, Yafei Cai, Siyang Liu, Sai Karthik Kodeboyina, Nikhil Patel, Natasha M. Savage, Ashok Sharma, Randal J. Kaufman, Honglin Li, Nagendra Singh
Published 2019-03-01

Fine tuning of the UPR by the ubiquitin ligases Siah1/2.

by Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J Kaufman, Ze'ev A Ronai
Published 2014-05-01

PDIA1/P4HB is required for efficient proinsulin maturation and ß cell health in response to diet induced obesity

by Insook Jang, Anita Pottekat, Juthakorn Poothong, Jing Yong, Jacqueline Lagunas-Acosta, Adriana Charbono, Zhouji Chen, Donalyn L Scheuner, Ming Liu, Pamela Itkin-Ansari, Peter Arvan, Randal J Kaufman
Published 2019-06-01

Proinsulin misfolding is an early event in the progression to type 2 diabetes

by Anoop Arunagiri, Leena Haataja, Anita Pottekat, Fawnnie Pamenan, Soohyun Kim, Lori M Zeltser, Adrienne W Paton, James C Paton, Billy Tsai, Pamela Itkin-Ansari, Randal J Kaufman, Ming Liu, Peter Arvan
Published 2019-06-01

eIF2α confers cellular tolerance to S. aureus α-toxin

by Gisela evon Hoven, Claudia eNeukirch, Sabine eFüser, Maria eBidna Petrivna, Martina eMeyenburg, Amable J. Rivas, Alexey eRyazanov, Randal J. Kaufman, Raffi V. Aroian, Matthias eHusmann
Published 2015-07-01

ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis

by Diane DeZwaan-McCabe, Ryan D. Sheldon, Michelle C. Gorecki, Deng-Fu Guo, Erica R. Gansemer, Randal J. Kaufman, Kamal Rahmouni, Matthew P. Gillum, Eric B. Taylor, Lynn M. Teesch, D. Thomas Rutkowski
Published 2017-05-01

Disulfiram (Antabuse) Activates ROS-Dependent ER Stress and Apoptosis in Oral Cavity Squamous Cell Carcinoma

by Priyanka Shah O’Brien, Yue Xi, Justin R. Miller, Amy L. Brownell, Qinghua Zeng, George H. Yoo, Danielle M. Garshott, Matthew B. O’Brien, Anthony E. Galinato, Peter Cai, Neha Narula, Michael U. Callaghan, Randal J. Kaufman, Andrew M. Fribley
Published 2019-05-01