Beth Stevens

Beth Stevens (born 1970) is an associate professor in the Department of Neurology at Harvard Medical School and the F. M. Kirby Neurobiology Center at Boston Children’s Hospital. She has helped to identify the role of microglia and complement proteins in the "pruning" or removal of synaptic cells during brain development, and has also determined that the impaired or abnormal microglial function could be responsible for diseases like autism, schizophrenia, and Alzheimer's.

In 2012, Stevens’s team published evidence that microglia 'eat' synapses, especially those that are weak and unused. These findings pinned down a new role for microglia in wiring the brain, indicating that adult neural circuitry is determined not only by nerve cells but also by the brain’s immune cells. This helped to explain how the brain, which starts out with a surplus of neurons, trims some of the excess neurons away. ''Neuron'' named the paper its most influential publication of 2012. Provided by Wikipedia
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  1. 1
    Experience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1
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  2. 2
    Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
    by HD iPSC Consortium, Lim, Ryan G, Salazar, Lisa L, Wilton, Daniel K, King, Alvin R, Stocksdale, Jennifer T, Sharifabad, Delaram, Lau, L Alice, Stevens, Beth, Reidling, Jack C, Winokur, Sara T, Casale, Malcolm S, Thompson, Leslie M, Pardo, Mónica, Díaz-Barriga, A Gerardo García, Straccia, Marco, Sanders, Phil, Alberch, Jordi, Canals, Josep M, Kaye, Julia A, Dunlap, Mariah, Jo, Lisa, May, Hanna, Mount, Elliot, Anderson-Bergman, Cliff, Haston, Kelly, Finkbeiner, Steven, Allen, Nicholas D, Kemp, Paul J, Atwal, Ranjit Singh, Biagioli, Marta, Gusella, James F, MacDonald, Marcy E, Akimov, Sergey S, Arbez, Nicolas, Stewart, Jacqueline, Ross, Christopher A, Mattis, Virginia B, Tom, Colton M, Mattis, Virginia B, Tom, Colton M, Ornelas, Loren, Sahabian, Anais, Lenaeus, Lindsay, Mandefro, Berhan, Sareen, Dhruv, Svendsen, Clive N, Kedaigle, Amanda Joy, Wasylenko, Theresa Anne, Yildirim, Ferah, Ng, Christopher W., Milani, Pamela, Housman, David E, Fraenkel, Ernest
    Published 2018
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  3. 3
    Initiating Complement-Dependent Synaptic Refinement: Mechanisms of Neuronal C1q Regulation
    by Bialas, Allison Marilyn
    Published 2013
    Other Authors: “...Stevens, Beth...”
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  4. 4
    Innate Immune Molecules Direct Microglia-Mediated Developmental Synaptic Refinement
    by Lehrman, Emily Kate
    Published 2014
    Other Authors: “...Stevens, Beth...”
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