LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate long-term potentiation (LTP), effects that may be mediated by intra-neuronal oligomers uptake. Intrigued by these finding...

Full description

Bibliographic Details
Main Authors: Daniela Puzzo, Roberto Piacentini, Mauro Fá, Walter Gulisano, Domenica D Li Puma, Agnes Staniszewski, Hong Zhang, Maria Rosaria Tropea, Sara Cocco, Agostino Palmeri, Paul Fraser, Luciano D'Adamio, Claudio Grassi, Ottavio Arancio
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
amyloid-beta
tau
APP
synaptic plasticity
memory
Alzheimer's disease
Online Access:https://elifesciences.org/articles/26991

Internet

https://elifesciences.org/articles/26991

Similar Items