Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses

Neonatal T Follicular Helper Cells Are Lodged in a Pre-T Follicular Helper Stage Favoring Innate Over Adaptive Germinal Center Responses

T follicular helper (Tfh) cells have emerged as a critical limiting factor for controlling the magnitude of neonatal germinal center (GC) reactions and primary vaccine antibody responses. We compared the functional attributes of neonatal and adult Tfh cells at the transcriptomic level and demonstrat...

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Bibliographic Details
Main Authors: Beatris Mastelic-Gavillet, Maria Vono, Patrícia Gonzalez-Dias, Frederico Moraes Ferreira, Lucas Cardozo, Paul-Henri Lambert, Helder I. Nakaya, Claire-Anne Siegrist
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
T follicular helper cells
neonates
vaccines
adjuvant
transcriptional profile analysis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01845/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01845/full

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