Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy
Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor...
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doaj-0cb2a8ac9b20461fada44687ad3b03b32020-12-10T07:38:05ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-12-011010.3389/fonc.2020.586580586580Macrophages in Osteosarcoma Immune Microenvironment: Implications for ImmunotherapyZhong-Wei Luo0Zhong-Wei Luo1Pan-Pan Liu2Zhen-Xing Wang3Zhen-Xing Wang4Chun-Yuan Chen5Chun-Yuan Chen6Hui Xie7Hui Xie8Hui Xie9Hui Xie10Hui Xie11Hui Xie12Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, ChinaThe Department of Dermatology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, ChinaMovement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Sports Medicine, Xiangya Hospital, Central South University, Changsha, ChinaHunan Key Laboratory of Organ Injury, Aging and Regenerative Medicine, Changsha, ChinaHunan Key Laboratory of Bone Joint Degeneration and Injury, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaOsteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies.https://www.frontiersin.org/articles/10.3389/fonc.2020.586580/fullosteosarcomatumor microenvironmentmacrophagestumor-associated macrophages (TAMs)immunotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zhong-Wei Luo Zhong-Wei Luo Pan-Pan Liu Zhen-Xing Wang Zhen-Xing Wang Chun-Yuan Chen Chun-Yuan Chen Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie |
spellingShingle |
Zhong-Wei Luo Zhong-Wei Luo Pan-Pan Liu Zhen-Xing Wang Zhen-Xing Wang Chun-Yuan Chen Chun-Yuan Chen Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy Frontiers in Oncology osteosarcoma tumor microenvironment macrophages tumor-associated macrophages (TAMs) immunotherapy |
author_facet |
Zhong-Wei Luo Zhong-Wei Luo Pan-Pan Liu Zhen-Xing Wang Zhen-Xing Wang Chun-Yuan Chen Chun-Yuan Chen Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie Hui Xie |
author_sort |
Zhong-Wei Luo |
title |
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy |
title_short |
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy |
title_full |
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy |
title_fullStr |
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy |
title_full_unstemmed |
Macrophages in Osteosarcoma Immune Microenvironment: Implications for Immunotherapy |
title_sort |
macrophages in osteosarcoma immune microenvironment: implications for immunotherapy |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-12-01 |
description |
Osteosarcoma is a malignant primary bone tumor commonly occurring in children and adolescents. The treatment of local osteosarcoma is mainly based on surgical resection and chemotherapy, whereas the improvement of overall survival remains stagnant, especially in recurrent or metastatic cases. Tumor microenvironment (TME) is closely related to the occurrence and development of tumors, and macrophages are among the most abundant immune cells in the TME. Due to their vital roles in tumor progression, macrophages have gained increasing attention as the new target of tumor immunotherapy. In this review, we present a brief overview of macrophages in the TME and highlight the clinical significance of macrophages and their roles in the initiation and progression of osteosarcoma. Finally, we summarize the therapeutic approaches targeting macrophage, which represent a promising strategy in osteosarcoma therapies. |
topic |
osteosarcoma tumor microenvironment macrophages tumor-associated macrophages (TAMs) immunotherapy |
url |
https://www.frontiersin.org/articles/10.3389/fonc.2020.586580/full |
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