Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway

Overexpression of PRDM5 promotes acute myeloid leukemia cell proliferation and migration by activating the JNK pathway

Abstract PRDM family proteins are dysregulated in many human diseases, especially hematological malignancies and solid cancers, and share a unique N‐terminal PR domain followed by zinc fingers toward the C terminus. With a high frequency of DNA promoter hypermethylation, PRDM5 is primarily considere...

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Bibliographic Details
Main Authors: Pan Zhou, Xing Chen, Mengke Li, Xiaolu Sun, Jiaqi Tan, Xiaomin Wang, Yajing Chu, Yicheng Zhang, Tao Cheng, Jianfeng Zhou, Gaoxiang Wang, Weiping Yuan
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Cancer Medicine
Subjects:
acute myeloid leukemia
c‐Myc
JNK
migration
PRDM5
proliferation
Online Access:https://doi.org/10.1002/cam4.2261

Internet

https://doi.org/10.1002/cam4.2261

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