Sample size requirements for separating out the effects of combination treatments: Randomised controlled trials of combination therapy vs. standard treatment compared to factorial designs for patients with tuberculous meningitis

<p>Abstract</p> <p>Background</p> <p>In certain diseases clinical experts may judge that the intervention with the best prospects is the addition of two treatments to the standard of care. This can either be tested with a simple randomized trial of combination versus st...

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Bibliographic Details
Main Authors: Farrar Jeremy, Caws Maxine, Yen Nguyen, Chau Tran, Heemskerk Dorothee, Wolbers Marcel, Day Jeremy
Format: Article
Language:English
Published: BMC 2011-02-01
Series:Trials
Online Access:http://www.trialsjournal.com/content/12/1/26