Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm

Tbx3 Controls Dppa3 Levels and Exit from Pluripotency toward Mesoderm

Tbx3, a member of the T-box family, plays important roles in development, stem cells, nuclear reprogramming, and cancer. Loss of Tbx3 induces differentiation in mouse embryonic stem cells (mESCs). However, we show that mESCs exist in an alternate stable pluripotent state in the absence of Tbx3. In-d...

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Bibliographic Details
Main Authors: Avinash Waghray, Néstor Saiz, Anitha D. Jayaprakash, Ana G. Freire, Dmitri Papatsenko, Carlos-Filipe Pereira, Dung-Fang Lee, Ran Brosh, Betty Chang, Henia Darr, Julian Gingold, Kevin Kelley, Christoph Schaniel, Anna-Katerina Hadjantonakis, Ihor R. Lemischka
Format: Article
Language:English
Published: Elsevier 2015-07-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115001526

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http://www.sciencedirect.com/science/article/pii/S2213671115001526

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