Health benefits of late-onset metformin treatment every other week in mice

Health benefits of late-onset metformin treatment every other week in mice

Intermittent use of metformin improves healthspan in old mice Chronic daily exposure to a high dose of metformin (e.g., 1% w/w) shortens lifespan of non-diabetic mice, although in the short term this treatment confers a similar pattern of gene expression and phenotypes consistent with the benefits o...

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Bibliographic Details
Main Authors: Irene Alfaras, Sarah J. Mitchell, Hector Mora, Darisbeth Rosario Lugo, Alessandra Warren, Ignacio Navas-Enamorado, Vickie Hoffmann, Christopher Hine, James R. Mitchell, David G. Le Couteur, Victoria C. Cogger, Michel Bernier, Rafael de Cabo
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:npj Aging and Mechanisms of Disease
Online Access:https://doi.org/10.1038/s41514-017-0018-7

Internet

https://doi.org/10.1038/s41514-017-0018-7

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