Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex

Morphogens function in concentration-dependent manners to instruct cell fate during tissue patterning. The cytoneme morphogen transport model posits that specialized filopodia extend between morphogen-sending and responding cells to ensure that appropriate signaling thresholds are achieved. How morp...

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Bibliographic Details
Main Authors: Eric T Hall, Miriam E Dillard, Daniel P Stewart, Yan Zhang, Ben Wagner, Rachel M Levine, Shondra M Pruett-Miller, April Sykes, Jamshid Temirov, Richard E Cheney, Motomi Mori, Camenzind G Robinson, Stacey K Ogden
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-02-01
Series:eLife
Subjects:
Cytoneme
signal transduction
morphogen
sonic hedgehog
cell biology
myosin
Online Access:https://elifesciences.org/articles/61432

Internet

https://elifesciences.org/articles/61432

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