NEURODEGENERATION CAUSED BY TRIMETHYLTIN VIA INHIBITION OF TROPOMYOSIN-RECEPTOR-KINASE B AND PHOSPHOINOSITIDE 3-KINASE/PROTEIN KINASE B SIGNALING CASCADE

NEURODEGENERATION CAUSED BY TRIMETHYLTIN VIA INHIBITION OF TROPOMYOSIN-RECEPTOR-KINASE B AND PHOSPHOINOSITIDE 3-KINASE/PROTEIN KINASE B SIGNALING CASCADE

Trimethyltin (TMT, 2.4mg/kg, i.p) can trigger neuronal damage by inhibiting Tropomyosin receptor kinase B (TrkB receptor) following by phosphoinositide 3-kinase (PI3K)/protein kinase B or Akt signaling cascade. We examined hippocampal changes in TrkA/B phosphorylation on Tyr490/Tyr516 of TMTtrea...

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Bibliographic Details
Main Authors: Tran Phi Hoang Yen, Nguyen Ngoc Khoi, Duong Phuoc An, Nguyen Thi Thu Van, Do Minh Quang
Format: Article
Language:English
Published: Universitas Gadjah Mada 2014-04-01
Series:Indonesian Journal of Pharmacy
Subjects:
trimethyltin
neurodegeneration
TrkB receptor
PI3K/Akt pathway
mice
Online Access:http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1

Internet

http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/1

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