Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

Fundamental pancreatic β-cell function is to produce and secrete insulin in response to blood glucose levels. However, when β-cells are chronically exposed to hyperglycemia in type 2 diabetes mellitus (T2DM), insulin biosynthesis and secretion are decreased together with reduced expression of insuli...

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Bibliographic Details
Main Authors: Hideaki Kaneto, Tomohiko Kimura, Masashi Shimoda, Atsushi Obata, Junpei Sanada, Yoshiro Fushimi, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic β-cells
glucose toxicity
arteriosclerosis
GLP-1 receptor agonist
incretin-based medicine
Online Access:https://www.mdpi.com/1422-0067/22/15/7917

Internet

https://www.mdpi.com/1422-0067/22/15/7917

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