Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients

Wnt/β-catenin signaling mediates the abnormal osteogenic and adipogenic capabilities of bone marrow mesenchymal stem cells from chronic graft-versus-host disease patients

Abstract Chronic graft-versus-host disease (cGVHD) is the main cause of non-relapse mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Mesenchymal stem cells (MSCs) in bone marrow (BM) remain unclear in the pathophysiology of cGVHD. In this study, we analyzed BM-MSCs fro...

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Bibliographic Details
Main Authors: Han-zhou Qi, Yi-ling Ye, Yuan Suo, Hong Qu, Hai-yan Zhang, Kai-bo Yang, Zhi-ping Fan, Fen Huang, Li Xuan, Yan-qiu Chen, Hua Jin, Qi-fa Liu
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03570-6

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https://doi.org/10.1038/s41419-021-03570-6

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