USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics

USP25 Regulates EGFR Fate by Modulating EGF-Induced Ubiquitylation Dynamics

Deregulated epidermal growth factor receptor (EGFR) signaling is a key feature in different stages of oncogenesis. One important mechanism whereby cancer cells achieve increased and uncontrolled EGFR signaling is escaping down-modulation of the receptor. Ubiquitylation of the EGFR plays a decisive r...

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Bibliographic Details
Main Authors: Carlos A. Niño, Nadine Wollscheid, Giovanni Giangreco, Elena Maspero, Simona Polo
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Biomolecules
Subjects:
EGFR
ubiquitin
ubiquitylation
deubiquitylating enzymes
cancer
Online Access:https://www.mdpi.com/2218-273X/10/11/1548

Internet

https://www.mdpi.com/2218-273X/10/11/1548

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