Sublingual Administration of Sildenafil Oro-dispersible Film: New Profiles of Drug Tolerability and Pharmacokinetics for PDE5 Inhibitors

Sublingual Administration of Sildenafil Oro-dispersible Film: New Profiles of Drug Tolerability and Pharmacokinetics for PDE5 Inhibitors

Objective: Type 5 phosphodiesterase inhibitors (PDE5i) are efficient drugs used for treatment of erectile dysfunction (ED); however, a large discontinuation rate due to major side effects is reported. The aim of this study was to evaluate the possible improvement of sildenafil (Sild) pharmacokinetic...

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Bibliographic Details
Main Authors: Luca De Toni, Maurizio De Rocco Ponce, Erica Franceschinis, Stefano Dall’Acqua, Roberto Padrini, Nicola Realdon, Andrea Garolla, Carlo Foresta
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Pharmacology
Subjects:
PDE5 inhibitors
drug formulation
sublingual route
erectile dysfunction
adverse drug reaction
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00059/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00059/full

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