Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells

Matrilin-3 Chondrodysplasia Mutations Cause Attenuated Chondrogenesis, Premature Hypertrophy and Aberrant Response to TGF-β in Chondroprogenitor Cells

Studies have shown that mutations in the matrilin-3 gene (MATN3) are associated with multiple epiphyseal dysplasia (MED) and spondyloepimetaphyseal dysplasia (SEMD). We tested whether MATN3 mutations affect the differentiation of chondroprogenitor and/or mesenchymal stem cells, which are precursors...

Full description

Bibliographic Details
Main Authors: Chathuraka T. Jayasuriya, Fiona H. Zhou, Ming Pei, Zhengke Wang, Nicholas J. Lemme, Paul Haines, Qian Chen
Format: Article
Language:English
Published: MDPI AG 2014-08-01
Series:International Journal of Molecular Sciences
Subjects:
matrilin-3
multiple epiphyseal dysplasia
spondyloepimetaphyseal dysplasia
chondroprogenitor
chondrogenesis
TGF-β
Online Access:http://www.mdpi.com/1422-0067/15/8/14555

Internet

http://www.mdpi.com/1422-0067/15/8/14555

Similar Items