Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis

Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis

Abstract Background Although the immunomodulatory properties of mesenchymal stem cells (MSCs) have been highlighted as a new therapy for autoimmune diseases, including rheumatoid arthritis (RA), the disease-specific characteristics of MSCs derived from elderly RA patients are not well understood. Me...

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Bibliographic Details
Main Authors: Hyeon-Jeong Lee, Won-Jae Lee, Sun-Chul Hwang, Yongho Choe, Saetbyul Kim, Eunyeong Bok, Sangyeob Lee, Seung-Joon Kim, Hyun-Ok Kim, Sun-A Ock, Hae-Sook Noh, Gyu-Jin Rho, Sang-Il Lee, Sung-Lim Lee
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cell-derived from the patient
Rheumatoid arthritis
Duration of inflammatory disease
Immunomodulation
Cellular senescence
Online Access:https://doi.org/10.1186/s13287-021-02453-z

Internet

https://doi.org/10.1186/s13287-021-02453-z

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