Genetic Investigation of Tricarboxylic Acid Metabolism during the Plasmodium falciparum Life Cycle

New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials. Herein, we describe 11 genetic knockout (KO) lines that delete six of the eight mitochondri...

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Bibliographic Details
Main Authors: Hangjun Ke, Ian A. Lewis, Joanne M. Morrisey, Kyle J. McLean, Suresh M. Ganesan, Heather J. Painter, Michael W. Mather, Marcelo Jacobs-Lorena, Manuel Llinás, Akhil B. Vaidya
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124715002648