Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

Assessing the function of pneumococcal neuraminidases NanA, NanB and NanC in in vitro and in vivo lung infection models using monoclonal antibodies

Streptococcus pneumoniae isolates express up to three neuraminidases (sialidases), NanA, NanB and NanC, all of which cleave the terminal sialic acid of glycan-structures that decorate host cell surfaces. Most research has focused on the role of NanA with limited investigations evaluating the roles o...

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Bibliographic Details
Main Authors: Philipp Janesch, Harald Rouha, Adriana Badarau, Lukas Stulik, Irina Mirkina, Marisa Caccamo, Katharina Havlicek, Barbara Maierhofer, Susanne Weber, Karin Groß, Jacqueline Steinhäuser, Manuel Zerbs, Cecilia Varga, Ivana Dolezilkova, Sabine Maier, Gerhild Zauner, Nels Nielson, Christine A. Power, Eszter Nagy
Format: Article
Language:English
Published: Taylor & Francis Group 2018-12-01
Series:Virulence
Subjects:
Streptococcus pneumoniae
neuraminidases NanA NanB NanC
human and mouse lung infection models
host-pathogen interactions
monoclonal antibodies
Online Access:http://dx.doi.org/10.1080/21505594.2018.1520545

Internet

http://dx.doi.org/10.1080/21505594.2018.1520545

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