The molecular and cellular insight into the toxicology of bortezomib-induced peripheral neuropathy

The molecular and cellular insight into the toxicology of bortezomib-induced peripheral neuropathy

The proteasome inhibitor bortezomib (BTZ) is a first-line antitumor drug, mainly used for multiple myeloma treatment. However, BTZ shows prominent toxicity in the peripheral nervous system, termed BTZ-induced peripheral neuropathy (BIPN). BIPN is characterized by neuropathic pain, resulting in a dos...

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Bibliographic Details
Main Authors: Wenping Yan, Zhanxun Wu, Yuyu Zhang, Dongsheng Hong, Xihao Dong, Lin Liu, Yuefeng Rao, Lili Huang, Xiangnan Zhang, Jiaying Wu
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Bortezomib-induced peripheral neuropathy
Pathological mechanisms
Schwann cells
Neurons
Astrocytes
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221008519

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http://www.sciencedirect.com/science/article/pii/S0753332221008519

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