Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies

Mechanisms of Beta-Cell Apoptosis in Type 2 Diabetes-Prone Situations and Potential Protection by GLP-1-Based Therapies

Type 2 diabetes (T2D) is characterized by chronic hyperglycemia secondary to the decline of functional beta-cells and is usually accompanied by a reduced sensitivity to insulin. Whereas altered beta-cell function plays a key role in T2D onset, a decreased beta-cell mass was also reported to contribu...

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Bibliographic Details
Main Authors: Safia Costes, Gyslaine Bertrand, Magalie A. Ravier
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
pancreatic beta-cells
islets
apoptosis
islet amyloid
lipotoxicity
glucotoxicity
Online Access:https://www.mdpi.com/1422-0067/22/10/5303

Internet

https://www.mdpi.com/1422-0067/22/10/5303

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