Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia

Impaired striatal D2 receptor function leads to enhanced GABA transmission in a mouse model of DYT1 dystonia

DYT1 dystonia is caused by a deletion in a glutamic acid residue in the C-terminus of the protein torsinA, whose function is still largely unknown. Alterations in GABAergic signaling have been involved in the pathogenesis of dystonia. We recorded GABA- and glutamate-mediated synaptic currents from a...

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Bibliographic Details
Main Authors: Giuseppe Sciamanna, Paola Bonsi, Annalisa Tassone, Dario Cuomo, Anne Tscherter, Maria Teresa Viscomi, Giuseppina Martella, Nutan Sharma, Giorgio Bernardi, David G. Standaert, Antonio Pisani
Format: Article
Language:English
Published: Elsevier 2009-04-01
Series:Neurobiology of Disease
Subjects:
Electrophysiology
Dystonia
D2 dopamine receptor
Medium Spiny neurons
Fast-spiking interneuron
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109000035

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http://www.sciencedirect.com/science/article/pii/S0969996109000035

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