Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation

Radiation injury to the lung is the result of acute and chronic free radical formation, and there are currently few effective means of mitigating such injury. Studies in rodents indicate that superoxide dismutase mimetics may be effective in this regard; however, studies in humans or large animals a...

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Bibliographic Details
Main Authors: John Mark Cline, Greg Dugan, John Daniel Bourland, Donna L. Perry, Joel D. Stitzel, Ashley A. Weaver, Chen Jiang, Artak Tovmasyan, Kouros Owzar, Ivan Spasojevic, Ines Batinic-Haberle, Zeljko Vujaskovic
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Antioxidants
Subjects:
superoxide dismutase mimetic
MnTnHex-2-PyP5+
irradiation
Macaca mulatta
lung injury
Online Access:http://www.mdpi.com/2076-3921/7/3/40

Internet

http://www.mdpi.com/2076-3921/7/3/40

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