Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

Reducing the Levels of Akt Activation by PDK1 Knock-in Mutation Protects Neuronal Cultures against Synthetic Amyloid-Beta Peptides

The Akt kinase has been widely assumed for years as a key downstream effector of the PI3K signaling pathway in promoting neuronal survival. This notion was however challenged by the finding that neuronal survival responses were still preserved in mice with reduced Akt activity. Moreover, here we sho...

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Bibliographic Details
Main Authors: Shaobin Yang, Sònia Pascual-Guiral, Rebeca Ponce, Lydia Giménez-Llort, María A. Baltrons, Ottavio Arancio, Jose R. Palacio, Victoria M. Clos, Victor J. Yuste, Jose R. Bayascas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
PDK1/Akt
knock-in mouse
Alzheimer disease
TACE α-secretase
unfolding protein response
Online Access:http://journal.frontiersin.org/article/10.3389/fnagi.2017.00435/full

Internet

http://journal.frontiersin.org/article/10.3389/fnagi.2017.00435/full

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