Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

Evaluating Imaging Biomarkers of Acquired Resistance to Targeted EGFR Therapy in Xenograft Models of Human Head and Neck Squamous Cell Carcinoma

Background: Overexpression of EGFR is a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Patients with HNSCC who respond to EGFR-targeted tyrosine kinase inhibitors (TKIs) eventually develop acquired resistance. Strategies to identify HNSCC patients likely to benefit from...

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Bibliographic Details
Main Authors: Lauren C. J. Baker, Arti Sikka, Jonathan M. Price, Jessica K. R. Boult, Elise Y. Lepicard, Gary Box, Yann Jamin, Terry J. Spinks, Gabriela Kramer-Marek, Martin O. Leach, Suzanne A. Eccles, Carol Box, Simon P. Robinson
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Oncology
Subjects:
HNSCC
EGFR
resistance
imaging
MRI
PET
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00271/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2018.00271/full

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