Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons

Lysosomal membrane permeabilization is involved in oxidative stress-induced apoptotic cell death in LAMP2-deficient iPSCs-derived cerebral cortical neurons

Patients with Danon disease may suffer from severe cardiomyopathy, skeletal muscle dysfunction as well as varying degrees of mental retardation, in which the primary deficiency of lysosomal membrane-associated protein-2 (LAMP2) is considerably associated. Owing to the scarcity of human neurons, the...

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Bibliographic Details
Main Authors: Cheuk-Yiu Law, Chung-Wah Siu, Katherine Fan, Wing-Hon Lai, Ka-Wing Au, Yee-Man Lau, Lai-Yung Wong, Jenny C.Y. Ho, Yee-ki Lee, Hung-Fat Tse, Kwong-Man Ng
Format: Article
Language:English
Published: Elsevier 2016-03-01
Series:Biochemistry and Biophysics Reports
Subjects:
LAMP2 deficiency
iPSCs-derived cerebral cortical neurons
Lysosomal membrane permeabilization
Oxidative stress-induced apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S240558081600011X

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http://www.sciencedirect.com/science/article/pii/S240558081600011X

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