In Vitro and In Vivo Investigation of the Angiogenic Effects of Liraglutide during Islet Transplantation.

In Vitro and In Vivo Investigation of the Angiogenic Effects of Liraglutide during Islet Transplantation.

INTRODUCTION:This study investigated the angiogenic properties of liraglutide in vitro and in vivo and the mechanisms involved, with a focus on Hypoxia Inducible Factor-1α (HIF-1α) and mammalian target of rapamycin (mTOR). MATERIALS AND METHODS:Rat pancreatic islets were incubated in vitro with 10 μ...

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Bibliographic Details
Main Authors: Allan Langlois, Carole Mura, William Bietiger, Elodie Seyfritz, Camille Dollinger, Claude Peronet, Elisa Maillard, Michel Pinget, Nathalie Jeandidier, Séverine Sigrist
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4790919?pdf=render

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http://europepmc.org/articles/PMC4790919?pdf=render

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