Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1–Enzalutamide Combination Treatment

Crosstalk of NF-κB/P65 and LncRNA HOTAIR-Mediated Repression of MUC1 Expression Contribute to Synergistic Inhibition of Castration-Resistant Prostate Cancer by Polyphyllin 1–Enzalutamide Combination Treatment

Background/Aims: Polyphyllin I (PPI), one of the steroidal saponins in Paris polyphylla, reportedly exhibits antitumor effects. However, the detailed mechanism underlying PPI, particularly in enhancing the effect of the androgen receptor inhibitor enzalutamide in controlling castration-resistant pro...

Full description

Bibliographic Details
Main Authors: SongTao Xiang, PeiLiang Zou, JingJing Wu, Fang Zheng, Qing Tang, Jianfu Zhou, Swei Sunny Hann
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
HOTAIR
MUC1
PPI
Enzalutamide
CRPC cells
NF-κB/p65
Online Access:https://www.karger.com/Article/FullText/490028

Internet

https://www.karger.com/Article/FullText/490028

Similar Items