Antioxidant Supplementation Reduces Genomic Aberrations in Human Induced Pluripotent Stem Cells

Antioxidant Supplementation Reduces Genomic Aberrations in Human Induced Pluripotent Stem Cells

Somatic cells can be reprogrammed to induced pluripotent stem cells (iPSCs) using oncogenic transcription factors. However, this method leads to genetic aberrations in iPSCs via unknown mechanisms, which may limit their clinical use. Here, we demonstrate that the supplementation of growth media with...

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Bibliographic Details
Main Authors: Junfeng Ji, Vivek Sharma, Suxia Qi, Meritxell Espino Guarch, Ping Zhao, Zhiwei Luo, Wenxia Fan, Yu Wang, Faridah Mbabaali, Dante Neculai, Miguel Angel Esteban, John D. McPherson, Nizar N. Batada
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221367111300129X

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http://www.sciencedirect.com/science/article/pii/S221367111300129X

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