Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells

Abstract Long interspersed element 1 (LINE-1, or L1) is a retrotransposon that constitutes ~ 17% of the human genome. Although ~ 6000 full-length L1s spread throughout the human genome, their biological significance remains undetermined. The L1 5′ untranslated region has bidirectional promoter activ...

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Bibliographic Details
Main Authors: Tomoyuki Honda, Yuki Nishikawa, Kensuke Nishimura, Da Teng, Keiko Takemoto, Keiji Ueda
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79197-y