Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

Studies of the genetic basis of drug response could help clarify mechanisms of drug action/metabolism, and facilitate development of genotype-based predictive tests of efficacy or toxicity (pharmacogenetics).We conducted a systematic review and field synopsis of pharmacogenetic studies to quantify t...

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Bibliographic Details
Main Authors: Michael V Holmes, Tina Shah, Christine Vickery, Liam Smeeth, Aroon D Hingorani, Juan P Casas
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2778625?pdf=render