Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

Glucocorticoids Reduce Aberrant O-Glycosylation of IgA1 in IgA Nephropathy Patients

Background/Aims: IgA nephropathy is associated with aberrant O-glycosylation of IgA1, which is recognized by autoantibodies leading to the formation of circulating immune complexes. Some of them, after deposition into kidney mesangium, trigger glomerular injury. In patients with active disease nonre...

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Bibliographic Details
Main Authors: Petr Kosztyu, Martin Hill, Jana Jemelkova, Lydie Czernekova, Leona Raskova Kafkova, Miroslav Hruby, Karel Matousovic, Karel Vondrak, Josef Zadrazil, Ivan Sterzl, Jiri Mestecky, Milan Raska
Format: Article
Language:English
Published: Karger Publishers 2018-03-01
Series:Kidney & Blood Pressure Research
Subjects:
Iga nephropathy
O-glycosylation
IgA1 hinge region
Circulating immune complexes
Galactose deficiency
Glycan-specific antibodies
Online Access:https://www.karger.com/Article/FullText/487903

Internet

https://www.karger.com/Article/FullText/487903

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