The Effects of Ascorbate, N-Acetylcysteine, and Resveratrol on Fibroblasts from Patients with Mitochondrial Disorders

The Effects of Ascorbate, N-Acetylcysteine, and Resveratrol on Fibroblasts from Patients with Mitochondrial Disorders

Reactive oxygen species (ROS) are assumed to be implicated in the pathogenesis of inborn mitochondrial diseases affecting oxidative phosphorylation (OXPHOS). In the current study, we characterized the effects of three small molecules with antioxidant properties (N-acetylcysteine, ascorbate, and resv...

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Bibliographic Details
Main Authors: Liza Douiev, Devorah Soiferman, Corinne Alban, Ann Saada
Format: Article
Language:English
Published: MDPI AG 2016-12-01
Series:Journal of Clinical Medicine
Subjects:
mitochondrial disease
fibroblast
ascorbate
N-acetylcysteine
resveratrol
ATP
ROS
OXPHOS
Online Access:http://www.mdpi.com/2077-0383/6/1/1

Internet

http://www.mdpi.com/2077-0383/6/1/1

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