Structural Determinants of Substrate Specificity of Omega-3 Desaturases from <i>Mortierella alpina</i> and <i>Rhizophagus irregularis</i> by Domain-Swapping and Molecular Docking

Structural Determinants of Substrate Specificity of Omega-3 Desaturases from <i>Mortierella alpina</i> and <i>Rhizophagus irregularis</i> by Domain-Swapping and Molecular Docking

Although various &#969;-3 fatty acid desaturases (&#969;3Des) have been identified and well-studied regarding substrate preference and regiospecificity, the molecular mechanism of their substrate specificities remains to be investigated. Here we compared two &#969;3Des, FADS15 from <i...

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Bibliographic Details
Main Authors: Chunchi Rong, Haiqin Chen, Xin Tang, Zhennan Gu, Jianxin Zhao, Hao Zhang, Yongquan Chen, Wei Chen
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
linoleic acid
arachidonic acid
omega-3 desaturases
chimera
domain-swapping
molecular docking
Online Access:https://www.mdpi.com/1422-0067/20/7/1603

Internet

https://www.mdpi.com/1422-0067/20/7/1603

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